Abstract #4590

Vascular-metabolic and GABAergic inhibitory modulation of neural variability. A combined fMRI and PET study

Pengmin Qin^1,2, Niall W Duncan², David Yen-Ting Chen³, Zirui Huang⁴, Chien-Yuan Eddy Lin^5,6, Christine Wiebking⁷, Chien-Mu Lin⁸, Che-Ming Yang⁸, Ying-Chi Tseng³, Georg Northoff⁹, and Timothy Lane²

¹Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, People's Republic of China, ²Brain and Consciousness Research Centre, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan, ³Department of Radiology, Taipei Medical University - Shuang Ho Hospital, New Taipei City, Taiwan, ⁴Mind, Brain Imaging and Neuroethics Research Unit, Institute of Mental Health Research, University of Ottawa, Ottawa, Canada, ⁵GE Healthcare, Taipei, Taiwan, ⁶GE Healthcare MR Research China, Beijing, People's Republic of China, ⁷Applied Emotion and Motivation Research, Institute for Psychology and Education, Universität Ulm, Ulm, Germany, ⁸Department of Nuclear Medicine, Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan, ⁹Brain and Mind Research Institute, Centre for Neural Dynamics, Faculty of Medicine, University of Ottawa, Ottawa, Canada

We sought to investigate the mechanism involved in temporal variability (TV) changes between two basic behavioral states, namely having the eyes open (EO) or eyes closed (EC). The aim of this study was to use the change between the EC and EO states to identify the potential mechanisms involved in TV modulation.

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