Abstract #4600

Traffic-Related Air Pollution Associated with Activation in a Functional MRI Verb Generation Task of a Longitudinally Studied, Pediatric Cohort

Kim M Cecil¹, Thomas Maloney¹, Mekibib Altaye², Rachel Severs², Christopher Wolfe², Zana Percy³, Travis Beckwith¹, Kimberly Yolton², Grace LeMasters³, and Patrick Ryan²

¹Radiology/Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ²Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ³University of Cincinnati College of Medicine, Cincinnati, OH, United States

Traffic-related air pollution (TRAP) is strongly associated with adverse cardiopulmonary health effects. Evidence suggests the developing brain may also be a target organ for particulate matter due to translocation either from the respiratory system or through the olfactory nerve. Using a pediatric cohort, we tested the hypothesis that exposure to TRAP during critical windows of brain development is significantly associated with changes in brain functioning during a language task. Children with high exposure levels were associated with reduced activation within the frontal lobe compared with children at low exposure.

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