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Abstract #4600

Traffic-Related Air Pollution Associated with Activation in a Functional MRI Verb Generation Task of a Longitudinally Studied, Pediatric Cohort

Kim M Cecil1, Thomas Maloney1, Mekibib Altaye2, Rachel Severs2, Christopher Wolfe2, Zana Percy3, Travis Beckwith1, Kimberly Yolton2, Grace LeMasters3, and Patrick Ryan2

1Radiology/Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 3University of Cincinnati College of Medicine, Cincinnati, OH, United States

Traffic-related air pollution (TRAP) is strongly associated with adverse cardiopulmonary health effects. Evidence suggests the developing brain may also be a target organ for particulate matter due to translocation either from the respiratory system or through the olfactory nerve. Using a pediatric cohort, we tested the hypothesis that exposure to TRAP during critical windows of brain development is significantly associated with changes in brain functioning during a language task. Children with high exposure levels were associated with reduced activation within the frontal lobe compared with children at low exposure.

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