Abstract #4603

Disrupted Brain Connectivity Patterns in patients with Attention-deficit/hyperactivity disorder

Ming Zhou¹, Chuang Yang², Xuan Bu¹, Haixi Lin², Yan Liang², Lu Lu¹, Lianqing Zhang¹, Xinyu Hu¹, and Xiaoqi Huang¹

¹Department of Radiology, Huaxi MR Research Center, Chengdu, People's Republic of China, ²Department of Psychiatry, The First Affiliated Hospital of Wenzhou Medical University, People's Republic of China

In the current study, we used a graph theory-based network measurements named degree centrality (DC) to identify main cortical hubs in the brain network architecture at voxel level affected in ADHD. Then, functional connectivity maps were generated with seeded at altered DC to detect the brain changes at large-scale level. Finally, we found the disconnection within cortico-thalamus and cortico-striatal loops in ADHD patients, which may associated with inattention and cognitive function deficits.

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