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Abstract #4605

Changes in fMRI activation pattern during different levels of sacral nerve stimulation for overactive bladder

Pallab Bhattacharyya1, Bradley Gill2, Javier Pizarro-Berdichevsky2,3,4, Howard Goldman2, Mark Lowe1, and Stephen Jones1

1Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, 2Glickman Urology & Kidney Institute, Cleveland Clinic, Cleveland, OH, United States, 3Urogynecology Unit, H. Dr. Sotero del Rio, Santiago, Chile, 4Division Obstetricia y Ginecologia, Pontificia Universidad Católica de Chile

Sacral nerve stimulation (SNS) is an effective treatment for refractory overactive bladder(OAB). For patient-specific and therapeutic efficacy, stimulus at levels below or above the sensory level are sometimes applied on OAB patients. Previous functional brain studies suggested that few forebrain circuits acting primarily on midbrain periacqueductal grey is responsible for facilitating voiding reflex and a sensation of voiding. The neural circuits underlying the action of SNS, and its response to different levels of stimulus is studied by functional MRI (fMRI). Differences in activation patterns resulting from subsensoy, sensory and supresensory stimulation are reported.

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