Abstract #4607

Abnormal Local Functional Connectivity Density in Major Depressive Disorder Patients with Suicidal Behavior

Ziqi Chen¹, Mingrui Xia², Weihong Kuang³, Zhiyun Jia^1,4, Yong He⁵, and Qiyong Gong^1,6

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, People's Republic of China, ²State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, People's Republic of China, ³Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, People's Republic of China, ⁴Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, People's Republic of China, ⁵State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, ⁶Department of Psychology, Sichuan University, Chengdu, People's Republic of China

Previous studies suggested abnormal functional connectivity related to suicide behavior, which however relied on priori selection of seed regions. We applied functional connectivity density (FCD) to investigate the short-range and long-range functional connectivity patterns in major depressive disorder (MDD) patients with suicidal behavior. Relative to healthy controls, MDD patients with suicidal behavior showed reduced short-range FCD in bilateral thalamus, left hippocampus and increased short-range FCD in left precuneus. This study demonstrated altered local connectivity density at voxel level in MDD patients with suicidal behavior and highlighted that the thalamus, hippocampus and precuneus were important brain network hubs for these patients.

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