Asymptomatic unilateral internal carotid stenosis is associated with brain hemodynamic changes and cognitive impairment. However, the effects on Gray Matter (GM) volume, Cerebral Blood Flow (CBF) and Functional Connectivity (FC) are not clear. Therefore, the present study aims to assess changes in brain volume, CBF, resting-state FC and their relation to cognitive decline in a group of patients at presymptomatic stage using MRI. This study confirmed abnormalities in GM volume, CBF, RSBNs and RS-FC in patients, showing that MRI have great potential as biomarker of the disease and may provide additional information to predict cases at risk of brain ischemia.
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