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Abstract #4615

The potential of MRI as a biomarker in elderly patients with asymptomatic unilateral internal carotid artery stenosis

Pedro Henrique Rodrigues Silva1, Ana Paula Afonso Camargo2, André Monteiro Paschoal1, Octavio M Pontes-Neto2, and Renata Ferranti Leoni1

1Department of Physics, FFCLRP, University of Sao Paulo, Ribeirao Preto, Brazil, Ribeirão Preto, Brazil, 2Department of Neurosciences and Behavioral Science, FMRP, University of Sao Paulo, Ribeirao Preto, Brazil, Brazil

Asymptomatic unilateral internal carotid stenosis is associated with brain hemodynamic changes and cognitive impairment. However, the effects on Gray Matter (GM) volume, Cerebral Blood Flow (CBF) and Functional Connectivity (FC) are not clear. Therefore, the present study aims to assess changes in brain volume, CBF, resting-state FC and their relation to cognitive decline in a group of patients at presymptomatic stage using MRI. This study confirmed abnormalities in GM volume, CBF, RSBNs and RS-FC in patients, showing that MRI have great potential as biomarker of the disease and may provide additional information to predict cases at risk of brain ischemia.

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