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Abstract #4630

Feasibility of 1H-MRS brain temperature map to detect hemodynamic abnormality in patients with unilateral chronic major cerebral artery steno-occlusive disease

Takamasa Namba1, Kuniaki Ogasawara1, Hideaki Nishimoto1, Daiya Ishigaki1, Yoshichika Yoshioka2,3, Toshiyuki Murakami1, Makoto Sasaki4, Masakazu Kobayashi1, Kenji Yoshida1, Ikuko Uwano4, Shunrou Fujiwara1, Kazunori Terasaki5, and Akira Ogawa1

1Department of Neurosurgery, School of Medicine, Iwate Medical University, Morioka, Japan, 2Center for Information and Neural Networks (CiNet), NICT and Osaka University, Suita, Japan, 3Biofunctional Imaging, Immunology Frontier Reseach Center, Osaka University, Suita, Japan, 4Division of Ultra-High Field MRI, School of Medicine,Iwate Medical University, Morioka, Japan, 5Cyclotoron Reseach Center, School of Medicine, Iwate Medical University

Deep cerebral white matter (CWM) like the centrum semiovale is vulnerable to ischemic injury. Brain temperature (BT) was associated with cerebral hemodynamic abnormalities in patients with chronic ischemia. We investigated whether the BT distribution map by multi-voxel 1H-MRS were associated with the cerebral hemodynamic abnormalities assessed by positron emission tomography (PET) in the CWM region of patients with unilateral chronic major cerebral artery steno-occlusive disease. The BT map quantitatively and qualitatively correlated with PET images, especially oxygen extraction fraction. This may help to identify the patients at high risk for the stroke recurrence.

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