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Abstract #4641

Abnormal Thalamic Metabolism in End-Stage Renal Disease Patients with Restless Legs Syndrome

Xueying Ma1, Dun Ding1, Peng Li2, Fengli Liang1, Zhuonan Wang1, Yingxiang Sun1, Haining Li1, and Ming Zhang1

1Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China, 2Imaging Department, NO.215 Hospital of Shaanxi Nuclear Industry, Xianyang, People's Republic of China

Restless legs syndrome (RLS) was very common among ESRD patients. However, the physiopathologic mechanisms of RLS in ESRD patients were largely unclear. Here we analyzed the thalamic metabolites using 1H MRS and the correlation between sleep/RLS score and metabolites, compared with corresponding normal controls. The results showed that the Cho/Cr ratio increased and NAA/Cr ratio decreased in thalamus of ESRD patients. The correlation between Cho/Cr ratio and RLS score was significant. It indicated that the sleep disturbance in ESRD patients with RLS might be associated with the abnormal thalamocortical activation of human sleep regulation system.

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