Meeting Banner
Abstract #4656

Inhibitory Motor Dysfunction in Parkinson’s Disease Subtypes

Tao Gong1,2, Guangbin Wang3, Richard Edden4, Fei Gao3, Yuanyuan Xiang5, and Weibo Chen6

1MRI, Shandong Medical Imaging Research Institute, Shandong University, Jinan, People's Republic of China, 2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins university, Baltimore, MD, United States, 3MRI, Shandong Medical Imaging Research Institute, 4Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins university, Baltimore, MD, 5Shandong University, 6MRI, Philips Healthcare, Shanhai, People's Republic of China

This study was aimed to evaluate the differences between PD motor subtypes of GABA+ levels using MEGA-PRESS. PD patients were classified into PIGD and TD groups; sixteen healthy controls were recruited. All subjects underwent 3T MR examination including MEGA-PRESS. We found that GABA+ concentration was lower in PD compared with controls; furthermore, the TD group was lower than PIGD. In PD patients, the GABA+ levels were correlated with UPDRS scores. The results suggest that GABAergic dysfunction may play an important role in the pathogenesis of Parkinson’s disease. MEGA-PRESS provides a valuable examination method to discriminate between PD motor subtypes.

This abstract and the presentation materials are available to members only; a login is required.

Join Here