Abstract #4656

Inhibitory Motor Dysfunction in Parkinson’s Disease Subtypes

Tao Gong^1,2, Guangbin Wang³, Richard Edden⁴, Fei Gao³, Yuanyuan Xiang⁵, and Weibo Chen⁶

¹MRI, Shandong Medical Imaging Research Institute, Shandong University, Jinan, People's Republic of China, ²Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins university, Baltimore, MD, United States, ³MRI, Shandong Medical Imaging Research Institute, ⁴Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins university, Baltimore, MD, ⁵Shandong University, ⁶MRI, Philips Healthcare, Shanhai, People's Republic of China

This study was aimed to evaluate the differences between PD motor subtypes of GABA+ levels using MEGA-PRESS. PD patients were classified into PIGD and TD groups; sixteen healthy controls were recruited. All subjects underwent 3T MR examination including MEGA-PRESS. We found that GABA+ concentration was lower in PD compared with controls; furthermore, the TD group was lower than PIGD. In PD patients, the GABA+ levels were correlated with UPDRS scores. The results suggest that GABAergic dysfunction may play an important role in the pathogenesis of Parkinson’s disease. MEGA-PRESS provides a valuable examination method to discriminate between PD motor subtypes.

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