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Abstract #4671

Reduced FOV with Multi-shot IRIS Provides Improved Diffusion Tensor Imaging in the Cervical Spinal Cord

Samantha By1,2, Ed Mojahed2,3, Saikat Sengupta2, and Seth A. Smith1,2,4

1Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 3Philips Healthcare, Nashville, TN, United States, 4Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

Spinal cord DTI is technically challenging, primarily due to the small size of the cord and physiological motion. We compare three different sequences to address these challenges: 1) single-shot EPI (ss-EPI), 2) multi-shot EPI with 2D navigation (IRIS), and 3) multi-shot EPI with reduced FOV (IRIS+iZOOM). Results indicate that IRIS alleviates geometric distortion present in ss-EPI. The combination of IRIS and iZOOM, however, provides the most consistent and least distorted diffusion-weighted images. These effects are clearly seen in the fractional anisotropy, axial diffusivity, and radial diffusivity maps, where exceptional contrast between gray and white matter are observed with IRIS+iZOOM.

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