Meeting Banner
Abstract #4678

Voxel-based analysis of grey and white matter degeneration above the level of injury in cervical spinal cord injury

Eveline Huber1, Gergely David1, Niklaus Weiskopf2,3, Siawoosh Mohammadi3,4, and Patrick Freund1,2,3,5

1University Hospital Balgrist, University of Zurich, Zurich, Switzerland, 2Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 3Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, London, United Kingdom, 4of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 5Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, London, United Kingdom

We studied the extent of cervical grey and white matter neurodegeneration above the level of injury after traumatic spinal cord injury (SCI) using high-resolution structural and diffusion MRI data. We found marked atrophy of both white and grey matter alongside diffusivity changes associated with axonal degeneration within the major spinal tracts. The extent of structural decline related to clinical impairment. These tract specific changes and clinicopathological relationships shed light into underlying neurodegenerative disease mechanisms, and therefore these measureable changes hold potential to serve as neuroimaging biomarkers of cord pathology.

This abstract and the presentation materials are available to members only; a login is required.

Join Here