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Abstract #4680

Microstructural assessment of the cervical spinal cord using high-resolution, 1 dimensional MRI

Rexford Newbould1 and Paul M Matthews2

1Imanova, London, United Kingdom, 2Division of Brain Sciences, Imperial College London, London, United Kingdom

A 1-dimensional MR sequence termed Fine Structural Analysis (fineSA) was applied to the human cervical spinal cord in order to determine if spinal tracts and nerve fibres of the dorsal horn could be identified from the spectral regularity of their myeloarchitecture. Repeatable 60 μm peaks could be attributed to the dorsal horn as opposed to projective nerve tracts of the cord. This analysis might be able to identify the loss of neurons via changes in packing density that would be proximal to macrostructural atrophy detectable on more classical MR sequences.

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