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Abstract #4686

Post-mortem and In Vivo Thalamic Nuclei Identification at 7T with Comparison to Histology

Mobeen Ali1, Ian Scott2, Alain Pitiot3, Karen Mullinger1,4, Andy Bagshaw4, Penny Gowland1, and Richard Bowtell1

1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2Department of Cellular Pathology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, 3School of Psychology, University of Nottingham, Nottingham, United Kingdom, 4Centre for Human Brain Health (CHBH), University of Birmingham, Birmingham, United Kingdom

The thalamus plays a major role in regulating the transfer of information through the brain and is also implicated in many neurodegenerative diseases. It is therefore crucial to improve our understanding of this key brain structure. Structural differentiation of thalamic nuclei in post-mortem 7T MRI was investigated. Thalamic sub-regions were identified in magnitude, R2*, R1 and magnetisation transfer ratio maps from six post-mortem brains. Edge detection, k-means clustering algorithms and thin-plate spline warping to the Morel atlas were used to systematically identify thalamic nuclei. These data showed good correlation with stained histological sections and in vivo MRI data.

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