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Abstract #4691

Measuring Transcortical Vasculature with Ultra-high Field (7T) MRI

Allen Timothy Newton1, Isabel Gauthier2, and Rankin W McGugin2

1Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 2Psychology, Vanderbilt University, Nashville, TN, United States

Direct visualization of intracortical vascular structure holds promise for detection of pathologic conditions currently invisible with conventional clinical MRI. However, imaging of these structures with MRI has been rare, and no validation of the technique has been performed. Here, we use 7T SWI to directly image intracortical vasculature on the microscopic scale with the goal of understanding the within and between subject variance. We found intracortical vascular measurements were reproducible within subjects and were sensitive to between subject variability, indicating that the measurements may be useful as a biomarker of disease processes affecting vasculature within the cortex.

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