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Abstract #4695

Relationship between nicotine dependence and the structural changes in the brain of young and middle-aged male smokers: a voxel-based morphometry study

Peng Peng1, Min Li1, Ya-Ru Tian1, Yang Yu1, Bin Jing2, Qing-Lei Shi3, and Tao Jiang1

1Radiology, Beijing Chao-Yang Hospital, Beijing, People's Republic of China, 2School of Biomedical Engineering, Capital Medical University, Beijing, People's Republic of China, 3MR Scientific Marketing, Siemens Healthcare Ltd. Diagnostic Imaging

This study aimed to research the relationship between the volume changes of brain and smoking extent/nicotine dependence. A voxel-based morphometry study between smokers grouped by smoking amount and dependence level was conducted. This study demonstrated the volume of many brain areas decreased with the increase in smoking extent and an opposite correlation between some brain areas and smoking dependence was observed. This study indicated that dependence had limited ability to predict smoking-related brain structure changes. A comprehensive assessment of the situation should be consulted, when clinicians make treatments options.

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