Abstract #4701

Grey matter atrophy measured in-vivo with 9.4T MRI in the experimental autoimmune encephalomyelitis mouse model of multiple sclerosis

A. Max Hamilton^1,2,3,4, Nils D. Forkert^1,2, Runze Yang^1,2,3,4, Ying Wu^1,2,3,4, James A. Rogers^2,3, V. Wee Yong^2,3, and Jeff F. Dunn^1,2,3,4

¹Department of Radiology, University of Calgary, Calgary, AB, Canada, ²Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, ³Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada, ⁴Experimental Imaging Center, University of Calgary, Calgary, AB, Canada

Grey matter atrophy has become a clinically relevant marker of progressive disability in multiple sclerosis (MS). To better study atrophy in MS, mouse models that have grey matter loss are needed. A possible candidate is the experimental autoimmune encephalomyelitis (EAE) mouse model. We used high-resolution magnetic resonance imaging (MRI) and atlas-based regional volumetrics to measure the volumes of 62 structures in the brains of EAE mice, 66 days post-induction. We identified atrophy in 19 structures including the cortex, cerebellum, striatum, thalamus, hippocampus, and corpus callosum. Using MRI we can study atrophy in this inflammatory model of MS.

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