Abstract #4704

Is the length of the white matter fiber bundles underlying the thalamo-cortical loop associated with sleep spindles? – a preliminary study

Pierre-Olivier Gaudreault^1,2, Julie Carrier^1,2,3, Maxime Descoteaux⁴, and Samuel Deslauriers-Gauthier⁴

¹Center for advanced research in sleep medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada, ²Department of Psychology, University of Montreal, Montreal, QC, Canada, ³Research Center, Institut universitaire de gériatrie de Montréal, Montreal, QC, Canada, ⁴Sherbrooke connectivity imaging lab, Computer science Department, University of Sherbrooke, Sherbrooke, QC, Canada

Sleep spindles, an EEG manifestation generated by the thalamo-cortical loop and implicated in sleep-dependent learning were recently associated to voxel-based metrics of brain white matter. Thus, we aimed to investigate if specific bundles of streamlines underlying the thalamo-cortical loop will be associated to sleep spindles variables in twenty-five young subjects. Our study showed that the median fiber length of streamlines connecting the thalamus to the anterior and middle part of the superior frontal gyrus significantly predicted sleep spindles amplitude and frequency measured on frontal and central electrodes.

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