Abstract #4711

A preliminary study on the amplitude of low frequency fluctuations in CADASIL

Mengxing Wang¹, Jingjing Su², Jilei Zhang¹, Hui Zhang¹, Jian-ren Liu², and Xiaoxia Du*¹

¹Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, Shanghai, People's Republic of China, ²Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China

The purpose of this study was to investigate spontaneous low-frequency fluctuations in CADASIL patients during resting-state fMRI scans. Eleven patients (aged, 33-66 years, 6 female) and 11 age- and gender-matched healthy controls were recruited. Amplitude of low-frequency fluctuation (ALFF) was calculated to measure spontaneous brain activity. The results showed that CADASIL patients exhibited significantly decreased ALFF in the bilateral precuneus, and increased ALFF in the midbrain/ pons, the insula/ temporal pole, and the anterior cingulate gyrus/ corpus callosum. Our study first provides empirical evidence for altered spontaneous neuronal activity in CADASIL patients.

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