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Abstract #4713

Analysis of capillary permeability index and stiffness variation during Ischemic Stroke: A first step towards evaluation of compressibility and neurodegenerative changes in Brain MRE

Raghu Prasad1, Jaganathan Vellagoundar2, and Kathryn M McMillan3

1GE Healthcare, Bangalore, India, 2GE Healthcare, India, 3GE Healthcare, Milwaukee, WI, United States

Evaluation of compressibility and neurodegenerative changes is critical for planning the therapy for ischemic stroke disorders. A key factor that was not analyzed till date is the capillary permeability of blood-brain-barrier (BBB) perturbations and localized mechanical degenerative changes inside the infarct region during ischemic stroke. Our results clearly indicate a decrease in stiffness of stroke-affected infarct tissue. CPI was observed to be less in the weak BBB regions.The results demonstrate through CP and stiffness maps that extent of tissue integrity that is degraded inside the infarcted region can be assessed efficiently

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