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Abstract #4719

Non-invasive MR Thermometry in a Non-human Primate Model of Acute Ischemic Stroke

Seena Dehkharghani1, Candace Fleischer2, Deqiang Qiu3, and Frank Tong4

1Radiology, New York University, New York, NY, United States, 2Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States, 3Radiology, Emory University, Atlanta, GA, United States, 4Radiology, Emory University

Temperature dysregulation is deeply implicated in potentiation of cerebrovascular ischemia. We present a multi-phasic, MR thermographic study in a non-human primate (NHP) model of MCA infarction, hypothesizing detectable brain temperature disturbances and brain-systemic temperature decoupling. Successful physiologic and continuous post-ischemic cerebral MR thermography was conducted, and prescribed in an NHP infarction model to facilitate translatability. The results confirm hypothesized temperature disturbance and decoupling of physiologic brain-systemic temperature gradients. These findings inform a developing paradigm of brain thermoregulation, and the applicability of brain temperature as a neuroimaging biomarker in CNS injury.

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