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Abstract #4721

Spectral Diffusion IVIM Analysis of Enlarged Perivascular Spaces in Cerebral Small Vessel Disease

Sau May Wong1, Jacobus F.A. Jansen1, C. Eleana Zhang2, Julie Staals2, Paul A.M. Hofman1, Robert J. van Oostenbrugge2, and Walter H. Backes1

1Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, Netherlands, 2Neurology, Maastricht University Medical Centre, Maastricht, Netherlands

The conventional IVIM model assumes a two-compartment model; this might not apply for regions with enlarged perivascular spaces (PVS) in cerebral small vessel disease (cSVD). Regularized non-negative least squared was used to deconvolve the IVIM signal in multiple diffusion components. Sixty-three cSVD patients and thirty-five controls received IVIM imaging and visual scoring of enlarged PVS. An additional component to the assumed parenchymal and perfusion components was revealed. We show that the fraction of this component is related to the amount of scored enlarged PVS. Quantifying PVS is a time-consuming process and this method might aid the development of automatic quantification.

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