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Abstract #4746

Mechanical stiffness of human brain tissue is inversely correlated with FA and MTR

Christoph Birkl1, Silvia Budday2, Gerhard Sommer3, Melanie Bauer2, Paul Steinmann2, Johannes Haybaeck4,5, Ellen Kuhl6, Gerhard A. Holzapfel3,7, Franz Fazekas1, Stefan Ropele1, and Christian Langkammer1

1Department of Neurology, Medical University of Graz, Graz, Austria, 2Department of Mechanical Engineering, University of Erlangen-Nuermberg, Erlangen, Germany, 3Institute of Biomechanics, Graz University of Technology, Graz, Austria, 4Department of Neuropathology, Institute of Pathology, Medical University of Graz, Graz, Austria, 5Department of Pathology, Medical Faculty, Otto-von-Guericke-University, Magdeburg, Germany, 6Departments of Mechanical Engineering and Bioengineering, Stanford University, CA, United States, 7Faculty of Engineering Science and Technology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

In this study, we investigated the mechanical stiffness of human brain tissue assessed by triaxial testing of post-mortem tissue specimens in relation to magnetization transfer ratio (MTR) and diffusion tensor MRI. Our results showed a strong inverse correlation of MTR and FA with the tissue stiffness. Anisotropy of the stiffness was not observed, which indicates that the neuronal fiber orientation does not mechanically support the tissue.

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