Abstract #4775

Evaluation of three-dimensional magnetic resonance imaging of autopsied human heart specimens for computational modeling of congenital heart diseases

Yoshiaki Morita¹, Wataru Ueki¹, Ryo Haraguchi², Takaaki Matsuayama³, Yoshiaki Watanabe¹, Tatsuya Nishii¹, Atsushi Kono¹, Naoaki Yamada¹, and Tetsuya Fukuda¹

¹Department of Radiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan, ²Division of Medical informatics, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan, ³Department of Pathology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan

This study aimed to compare the visibility of a formalin-fixed heart using various 3D MRI sequences as well as to determine the optimal sequence for computational modeling of congenital heart diseases. Our results demonstrated that MPRAGE showed the best contrast with good image quality for imaging of the myocardium and the vascular structure when surrounded by normal saline in a plastic container. We believe that computational cardiac modeling of human autopsied heart specimens using MPRAGE plays a critical role in education and/or research.

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