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Abstract #4785

Lower Normalised T2 Signal Intensity is Associated with Higher Intratumoural Heterogeneity: A Radiogenomic Study in High-Risk Prostate Cancer

Edward William Johnston1, Mark Linch2, Gerald Goh2, Crispin Hiley3, Yaalini Shanmugabavan4, Michela Antonelli5, Marco Gerlinger6, Andrew Rowan2, Yien Ning Sophia Wong2, Helen King 2, Andrew Furness7, Alexander Freeman8, Linares Linares7, Ayse Akarca7, Javier Herrero7, Stephan Dentro9, Nathalie Harder10, Guenter Schmidt10, Gareth A Gareth3, Nicholas McGranahan3, Nicolai Birkbak3, Richard Mitter3, Paul Cathcart11, Rebecca Scott4, Michelle Hung4, Mark Emberton4, Gert Attard12, Zoltan Szallasi13, Sergio Quezada7, Teresa Marafioti8, Sebastien Ourselin5, Hashim Ahmed4, Charles Swanton3, and Shonit Punwani1

1Centre for Medical Imaging, University College London, London, United Kingdom, 2Translational Cancer Therapeutics Laboratory, University College London, London, United Kingdom, 3Translational Cancer Therapeutics Laboratory, Francis Crick Institute, London, United Kingdom, 4Division of Surgery and Interventional Science, University College London, London, United Kingdom, 5Centre for Medical Image Computing, University College London, London, United Kingdom, 6Centre for Evolution and Cancer, The Institute of Cancer Research, 7Cancer Immunology Unit, University College London, 8Department of Pathology, University College London Hospital, University Street, United Kingdom, 9Department of Bioinformatics and Biostatistics, University College London, 10Definiens AG, 11Urology, Guy's and St. Thomas' NHS Trust, 12Treatment Resistance Laboratory, The Institute of Cancer Research, 13Centre for Biological Sequence 47 Analysis, Technical University of Denmark

Intratumoural heterogeneity (ITH) has been shown to predict overall survival in prostate cancer, and non-invasive biomarkers that can measure this genetic diversity would be welcome. In this study, we correlated imaging metrics derived from multiparametric prostate MRI with genomic heterogeneity indices and showed that low values of normalised T2 signal intensity within tumours are associated with a higher degree of mutational ITH. Our study shows the potential to use diagnostic imaging as a surrogate for genomic ITH in order to risk stratify patient for guiding management decisions.

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