Abstract #4785

Lower Normalised T2 Signal Intensity is Associated with Higher Intratumoural Heterogeneity: A Radiogenomic Study in High-Risk Prostate Cancer

Edward William Johnston¹, Mark Linch², Gerald Goh², Crispin Hiley³, Yaalini Shanmugabavan⁴, Michela Antonelli⁵, Marco Gerlinger⁶, Andrew Rowan², Yien Ning Sophia Wong², Helen King ², Andrew Furness⁷, Alexander Freeman⁸, Linares Linares⁷, Ayse Akarca⁷, Javier Herrero⁷, Stephan Dentro⁹, Nathalie Harder¹⁰, Guenter Schmidt¹⁰, Gareth A Gareth³, Nicholas McGranahan³, Nicolai Birkbak³, Richard Mitter³, Paul Cathcart¹¹, Rebecca Scott⁴, Michelle Hung⁴, Mark Emberton⁴, Gert Attard¹², Zoltan Szallasi¹³, Sergio Quezada⁷, Teresa Marafioti⁸, Sebastien Ourselin⁵, Hashim Ahmed⁴, Charles Swanton³, and Shonit Punwani¹

¹Centre for Medical Imaging, University College London, London, United Kingdom, ²Translational Cancer Therapeutics Laboratory, University College London, London, United Kingdom, ³Translational Cancer Therapeutics Laboratory, Francis Crick Institute, London, United Kingdom, ⁴Division of Surgery and Interventional Science, University College London, London, United Kingdom, ⁵Centre for Medical Image Computing, University College London, London, United Kingdom, ⁶Centre for Evolution and Cancer, The Institute of Cancer Research, ⁷Cancer Immunology Unit, University College London, ⁸Department of Pathology, University College London Hospital, University Street, United Kingdom, ⁹Department of Bioinformatics and Biostatistics, University College London, ¹⁰Definiens AG, ¹¹Urology, Guy's and St. Thomas' NHS Trust, ¹²Treatment Resistance Laboratory, The Institute of Cancer Research, ¹³Centre for Biological Sequence 47 Analysis, Technical University of Denmark

Intratumoural heterogeneity (ITH) has been shown to predict overall survival in prostate cancer, and non-invasive biomarkers that can measure this genetic diversity would be welcome. In this study, we correlated imaging metrics derived from multiparametric prostate MRI with genomic heterogeneity indices and showed that low values of normalised T2 signal intensity within tumours are associated with a higher degree of mutational ITH. Our study shows the potential to use diagnostic imaging as a surrogate for genomic ITH in order to risk stratify patient for guiding management decisions.

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