Abstract #4789

3T DCE-MRI Performance in Prostate Cancer Detection: Correlation of Different Kinetic Parameters in the Transition and Peripheral Zone Stratified by Gleason Score and Scanner B1+ field Heterogeneity

Nazanin H Asvadi¹, Kyung Hyun Sung², Pooria Khoshnoodi³, Pornphan Wibulpolprasert⁴, Tristan Grogan⁵, Anthony Sisk⁶, Robert Reiter⁷, and Steven Raman⁸

¹Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ²Department of Radiological Sciences, Bioengineering, and Biomedical Physics IDP, UCLA, Los Angeles, CA, United States, ³David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ⁴Radiology, Ramathibodi Hospital, Bangkok, Thailand, ⁵Division of General Internal Medicine and Health Services Research, UCLA, Los Angeles, CA, United States, ⁶Pathology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ⁷Urology, David Geffen School of Medicine, Los Angeles, CA, United States, ⁸Radiology, David Geffen School of Medicine, Los Angeles, CA, United States

To correlate 3T dynamic contrast-enhanced MRI (DCE-MRI) kinetic parameters in prostate cancer (PCa) in the transition zone (TZ) and peripheral zone (PZ) confirmed by whole mount histopathology (WMHP) stratified by Gleason Scores (GS) and inter-scanner B1+ field variation. This study demonstrates that clinically relevant heterogeneity between kinetic parameters in low and high grade PCa in the TZ & PZ exists.

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