Abstract #4793

Linking a multi-compartment T2 model to diffusion microstructure in prostate cancer

William Devine¹, Edward Johnston¹, Elisenda Bonet-Carne², Shonit Punwani¹, Daniel Alexander², and David Atkinson¹

¹Centre for Medical Imaging, University College London, London, United Kingdom, ²Centre for Medical Image Computing, University College London, London, United Kingdom

This work develops a multi-compartment T2 model for prostate imaging. We investigate whether this model can provide information about differences in tissue microstructure, such as those between normal prostate tissue and tumour, by comparing it to the VERDICT diffusion model6. The high correlations found between a number of the parameters suggest that the proposed model is capable of detecting some microstructural differences. In the future this method may be able to provide different and complementary microstructural information to current diffusion models.

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