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Abstract #4817

Histogram analysis of intravoxel incoherent motion parameters in assessing tumour diffusion and perfusion heterogeneity in cervical cancer before and after chemoradiotherapy

Jose Angelo Udal Perucho1, Elaine Yuen Phin Lee1, Wing Chi Lawrence Chan2, Nanjie Gong3, and Queenie Chan4

1Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, 2Department  of  Health  Technology  and  Informatics, The Hong Kong Polytechnic University, Hong Kong, 3University of California, Berkeley, CA, United States, 4Philips Healthcare, Hong Kong, Hong Kong

Histogram analysis of intravoxel incoherent motion (IVIM) diffusion-weighted MRI (DWI) could be a promising quantitative approach in assessing tumour heterogeneity. We retrospectively studied twenty-five patients with cervical cancer who had paired IVIM MRI examinations before and at week-4 of chemoradiotherapy treatment (CRT). We observed histogram skewness and kurtosis significantly decreased while mean and all percentiles significantly increased in apparent diffusion coefficient (ADC), true diffusion coefficient (D) and perfusion fraction (f) following treatment. Furthermore, these significant differences were not correlated with a change in primary tumour volume (PTV) following treatment.

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