Testicular ischemia is an acute disorder, which requires an accurate diagnosis whether the testis function is reversible or irreversible at the time of presentation; however, diagnostic test that predicts the functional reversibility of the ischemic testis has yet been established. This paper reports temporal metabolite changes for up to 24 hours after the onset of experimental testicular ischemia by using a 9.4-tesla magnetic resonance spectroscopy. We found the reduction in creatine levels in the testis under prolonged ischemic condition; hence, the alteration in creatine levels could be a possible metabolite marker that indicates the functional reversibility of the ischemic testis.
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