A multimodal and multiscale protocol was defined for the diagnosis of mice colorectal diseases. Based on endoluminal MRI, using dedicated endorectal coils, and optical modalities the protocol was assessed on a mouse model of colorectal cancer for a six-month period. Optical modalities were used for microscopic characterization of the surface of the colon wall where endoluminal MRI was used for in-depth macroscopic characterization and staging of lesions from inflammation to cancer. The protocol was then used to support in vivo MRS signal analysis that was used to assess the biochemical content of various anatomical structures (colon wall, visceral fat…).
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