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Abstract #4863

Characterization of renal parenchyma impairment in partial unilateral ureteral obstruction in mice with Intravoxel Incoherent Motion MR imaging

Maguelonne Pons1, Benjamin Leporq2, Liza Ali3, Marianne Alison3, Miguel Albuquerque1, Michel Peuchmaur4, Marie-Laurence Poli Mérol5, Ulrich Blank1, Simon Auguste Lambert2, and Alaa El Ghoneimi4

1INSERM UMR 1149, Paris, France, 2Univ Lyon, INSA‐Lyon, Université Claude Bernard Lyon 1, 3Hôpital Robert Debré, APHP, Université Paris Diderot, Sorbonne Paris Cité, 4Pediatric Surgery and Urology, Hôpital Robert Debré, APHP, Université Paris Diderot, Sorbonne Paris Cité, 5Université Reims Champagne Ardennes,American Memorial Hospital

Ureteropelvic junction obstruction constitutes a major cause of progressive pediatric renal disease. To date the follow-up of patients is difficult because there is a lack of non-invasive biomarkers. Here we propose to quantitatively characterize impairment of the kidney parenchyma after partial unilateral ureteral obstruction (pUUO) on mice using an intravoxel incoherent motion diffusion sequence. The results suggest that an f reduction is associated with a decrease in the volume of the renal parenchyma, which could be related to decreased renal vascularization. The later may occur before impairment by fibrosis and the findings are in accordance with the literature on pUUO.

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