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Abstract #4868

Fatty acid composition with metabolic changes of livers from high fat diet-fed mice using in vivo and in vitro proton magnetic resonance spectroscopy

Kyu-Ho Song1, Min-Young Lee1, Chi-Hyeon Yoo1, Song-I Lim1, and Bo-Young Choe1

1Department of Biomedical Engineering, and Research Institute of Biomedical Engineering, The Catholic University of Korea College of Medicine, Seoul, Korea, Republic of

Our animal studies suggest that unsaturated fatty acids may be upregulated or downregulated in a chronic model of non-alcoholic fatty liver disease (NAFLD). Further assessment of the strengths of our analytical parameters, which is essential for research and clinical evaluation of disease, should account for signal decay and bias in sequence selection. This will provide an effective means to quantify lipid content and to characterize NAFLD.

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