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Abstract #4903

Hyperpolarised 3He Diffusion-Weighted MRI in Mild Cystic Fibrosis Children and Age-matched Healthy Controls

Ho-Fung Chan1, Guilhem J Collier1, Laurie Smith1,2, Helen Marshall1, Juan Parra-Robles1, Felix C Horn1, Graham Norquay1, Neil J Stewart1, Chris J Taylor2, Ina Aldag2, Alex Horsley3, and Jim M Wild1

1Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom, 2Sheffield Children's Hospital, Sheffield, United Kingdom, 3Manchester Adult CF Centre, Manchester, United Kingdom

Hyperpolarised gas MRI is sensitive to lung ventilation heterogeneity in early cystic fibrosis (CF) disease. However, lung microstructural changes that might accompany early lung disease in CF is less well explored. DW-MRI measurements were compared in mild CF children and age-matched healthy controls, and reassessed after a 2-year interval in the CF group. No significant difference in DW-MRI metrics (in contrast to changes in lung ventilation, VD%) was observed between healthy controls and CF children, and between baseline and 2-year follow-up visits. These results suggest that no acinar microstructural changes occur in early stage CF despite increases in ventilation heterogeneity.

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