Spirometry provides global measures of lung function, whereas CT provides morphologic information but limited functional information. Current tests are limited in providing spatially resolved function of each lung separately. To address this need, we have developed a 4D ultra-short echo time MRI method where respiratory motion information is extracted directly from the acquired k-space data during normal and deep breathing maneuvers, and motion-resolved reconstruction is performed to extract spatially resolved functional information of each lung. Such a method will improve the ability to diagnose and manage Chronic Obstructive Pulmonary Disease, which is a major cause of death worldwide.
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