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Abstract #4928

3T full breast diffusion imaging at sub-millimeter resolution with high immunity to artifacts

Eddy Solomon1, Gilad Liberman1, Noam Nissan2, Edna Furman-Haran3, Miri Sklair-Levy4, and Lucio Frydman1

1chemical Physics, Weizmann Institute of Science, Rehovot, Israel, 2Radiology, Sheba-Medical-Center, 3Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel, 4Sackler School of Medicine,Tel Aviv University

SPatio-temporal ENcoding (SPEN) MRI has been recenlty employed to quantify apparent diffusion coefficients in breast and in other challenging organs, thanks to its high immunity to B0-inhomogeneities and to chemical shift heterogeneities. In this study a new SPEN protocol is proposed combing multi-band pulses providing full coverage of both breasts with improved signal-noise-ratio, and multi-shot interleaved acquisitions achieving sub-millimeter spatial resolution. This provides a representation of the anatomical features that is similar to TSE, plus diffusion information containing insight into a lesion’s nature. Validations and examples are shown at 3T, including healthy female volunteers and patients with breast malignancies.

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