SPatio-temporal ENcoding (SPEN) MRI has been recenlty employed to quantify apparent diffusion coefficients in breast and in other challenging organs, thanks to its high immunity to B0-inhomogeneities and to chemical shift heterogeneities. In this study a new SPEN protocol is proposed combing multi-band pulses providing full coverage of both breasts with improved signal-noise-ratio, and multi-shot interleaved acquisitions achieving sub-millimeter spatial resolution. This provides a representation of the anatomical features that is similar to TSE, plus diffusion information containing insight into a lesion’s nature. Validations and examples are shown at 3T, including healthy female volunteers and patients with breast malignancies.
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