Abstract #4942

Investigating the role of DCE-MRI, over T2 and DWI, in accurate PIRADS-v2 assessment of clinically significant peripheral zone prostate lesions, as defined at radical prostatectomy

Mehdi Taghipour¹, Elmira Hassanzadeh¹, Francesco Alessandrino², Mukesh Harisinghani³, Clare M.C Tempany¹, and Fiona M Fennessy^1,2

¹Radiology, Harvard Medical School, Brigham and Women's Hospital, BOSTON, MA, United States, ²Imaging, Dana-Farber Cancer Institute, Boston, MA, United States, ³Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States

DCE has a secondary role in detecting peripheral zone lesions using PIRADS v2 and is limited to PZ lesion with DWI score of 3. The goals of this study are to determine the frequency with which DCE plays a role changing the final PI-RADS assessment score for PZ lesions, and 2) determine the accuracy of DCE-MRI in upgrading the assessment score . 271 patients with biopsy proven prostate cancer diagnosis, a mp-MRI, and who underwent curative radical prostatectomy were included in the study. DCE played a role only in 16.6% (45/271) of patients and showed sensitivity of 63.8% in upgrading lesions. In conclusion, the added value of DCE to T2-WI and DWI is very limited in diagnosis of csPC.

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