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Abstract #4951

Impact of Temporal Resolution on Quantitative DCE-DISCO Measurements in Prostate Cancer

James A Rioux1,2,3, Peter M Lakner1,4, Steve Patterson1, Mark Parker1,5, Jennifer Merrimen6, Cheng Wang6, Chris V Bowen1,2,3, and Sharon Clarke1,2,3

1Biomedical Translational Imaging Centre (BIOTIC), Nova Scotia Health Authority, Halifax, NS, Canada, 2Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada, 3Physics and Atmospheric Science, Dalhousie University, Halifax, NS, Canada, 4Computer Science, Dalhousie University, Halifax, NS, Canada, 5School of Health Sciences, Dalhousie University, Halifax, NS, Canada, 6Pathology, Dalhousie University, Halifax, NS, Canada

Depending on the particular application, the temporal resolution of dynamic contrast-enhanced MRI may have an impact on measurements of quantitative parameters related to contrast agent kinetics. In this study we retrospectively altered the temporal resolution of DCE-DISCO acquisitions in patients with prostate cancer, and examined the effect on the rate constant Ktrans in both normal tissue and cancer (as confirmed by histopathology). The difference in mean Ktrans values between tissue types was found to vary significantly with temporal resolution between 4 and 10s, suggesting that the uptake dynamics in cancer are more accurately sampled at higher temporal resolution.

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