Abstract #4951

Impact of Temporal Resolution on Quantitative DCE-DISCO Measurements in Prostate Cancer

James A Rioux^1,2,3, Peter M Lakner^1,4, Steve Patterson¹, Mark Parker^1,5, Jennifer Merrimen⁶, Cheng Wang⁶, Chris V Bowen^1,2,3, and Sharon Clarke^1,2,3

¹Biomedical Translational Imaging Centre (BIOTIC), Nova Scotia Health Authority, Halifax, NS, Canada, ²Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada, ³Physics and Atmospheric Science, Dalhousie University, Halifax, NS, Canada, ⁴Computer Science, Dalhousie University, Halifax, NS, Canada, ⁵School of Health Sciences, Dalhousie University, Halifax, NS, Canada, ⁶Pathology, Dalhousie University, Halifax, NS, Canada

Depending on the particular application, the temporal resolution of dynamic contrast-enhanced MRI may have an impact on measurements of quantitative parameters related to contrast agent kinetics. In this study we retrospectively altered the temporal resolution of DCE-DISCO acquisitions in patients with prostate cancer, and examined the effect on the rate constant K^trans in both normal tissue and cancer (as confirmed by histopathology). The difference in mean K^trans values between tissue types was found to vary significantly with temporal resolution between 4 and 10s, suggesting that the uptake dynamics in cancer are more accurately sampled at higher temporal resolution.

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