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Abstract #4957

Poor enhancement of colorectal liver metastases on delayed phase gadobutrol enhanced MRI may be related to increased number of APC mutations

Helen Cheung1, Arun Seth2, Yutaka Amemiya2, Eugene Hsieh3, Paul Karanicolas3, Natalie Coburn3, Xiaoyang Liu3, Vikrum Seth2, Calvin Law3, and Laurent Milot1

1Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada, 2Sunnybrook Research Institute, 3Sunnybrook Health Sciences Centre

We recently demonstrated that delayed enhancement of colorectal liver metastases (CRLM) on gadobutrol-enhanced MRI is associated with long-term survival. We performed a hypothesis-generating pilot study to determine whether delayed enhancement on MRI is related to the number and types of genetic mutations. There were a greater number of somatic APC mutations in hypoenhancing tumors compared to isoenhancing tumors or hyperenhancing tumors (N=15, p=0.013). There was no difference in the number of germline mutations or number of overall somatic mutations among MRI groups. Poor enhancement of CRLM on delayed phase gadobutrol-enhanced MRI may correlate with increasing number of somatic APC mutations.

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