Abstract #4957

Poor enhancement of colorectal liver metastases on delayed phase gadobutrol enhanced MRI may be related to increased number of APC mutations

Helen Cheung¹, Arun Seth², Yutaka Amemiya², Eugene Hsieh³, Paul Karanicolas³, Natalie Coburn³, Xiaoyang Liu³, Vikrum Seth², Calvin Law³, and Laurent Milot¹

¹Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada, ²Sunnybrook Research Institute, ³Sunnybrook Health Sciences Centre

We recently demonstrated that delayed enhancement of colorectal liver metastases (CRLM) on gadobutrol-enhanced MRI is associated with long-term survival. We performed a hypothesis-generating pilot study to determine whether delayed enhancement on MRI is related to the number and types of genetic mutations. There were a greater number of somatic APC mutations in hypoenhancing tumors compared to isoenhancing tumors or hyperenhancing tumors (N=15, p=0.013). There was no difference in the number of germline mutations or number of overall somatic mutations among MRI groups. Poor enhancement of CRLM on delayed phase gadobutrol-enhanced MRI may correlate with increasing number of somatic APC mutations.

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