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Abstract #4966

Metabolic Imaging of β3-adrenoreceptor Activated BAT and its Systemic Effect on Abdominal Fat in Diet Induced Obese Model

Jadegoud Yaligar1, Sanjay Kumar Verma 1, Venkatesh Gopalan 1, Anantharaj Rengaraj1, Tian Xianfeng1, Anna Ulyanova1, Bhanu Prakash K.N1, Suresh Anand Sadananthan2, Navin Michael2, and S. Sendhil Velan 1

1Laboratory of Metabolic Imaging, Singapore Bioimaging Consortium, A*STAR, Singapore, 2Singapore Institute for Clinical Sciences, A*STAR, Singapore

Imbalance in dietary intake and energy expenditure are associated with obesity, diabetes and metabolic disorders. Adipocyte size and expansion of adipose tissue plays a critical role towards the progression of diet induced obesity. Brown adipose tissue (BAT) plays a critical role in modulating different fat depots in the body. BAT can be functionally activated by administering the β3-adrenergic agonist. Understanding the mechanisms associated with BAT activation and the possibility of reversing insulin resistance and its impact on whole body metabolism is of current clinical interest for combating diabetes. In the current study, we investigated the fat partitioning in high fat diet induced obese rodent model by β-adrenergic-mediated BAT activation.

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