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Abstract #4977

Pretreatment diffusion kurtosis imaging for predicting the response of locally advanced rectal cancer to neoadjuvant chemoradiation therapy

Hongliang Sun1, Yanyan Xu1, Kaining Shi2, and Wu Wang1

1Radiology, China-Japan Friendship Hospital, Beijing, People's Republic of China, 2Philips Healthcare China, Beijing, People's Republic of China

Diffusion kurtosis imaging (DKI) is an emerging technique, which could reflect restricted water diffusion within the complex microstructure of most tissues based on non-Gaussian diffusion model. It has been reported that DKI was used in central system diseases, tumor grade, even assessment of treatment response. However, there is limited research reported about the clinical application of DKI in rectal cancer, and the value of DKI in monitoring rectal cancer treatment was still unclear.

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