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Abstract #4995

Diurnal changes of Acetylcarnitine in human vastus lateralis muscle and response to exercise: a 7T 1H MRS study

Radka Klepochová1,2,3, Ladislav Valkovič3,4,5, Martin Gajdošík1,3,6, Thomas Hochwartner7, Norbert Bachl 7, Harald Tschan7, Michael Krebs6, Siegfried Trattnig1,3, and Martin Krššák1,3,6

1High-Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 2Department of NMR Spectroscopy and Mass Spectrometry, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovakia, 3Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 4University of Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, 5Department of Imaging Methods, Institute of Measurements Science, Slovak Academy of Sciences, Bratislava, Slovakia, 6Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria, 7Center of Sport Science and University Sport, University of Vienna, Vienna, Austria

Carnitine plays an important role in fat metabolism. A long-echo time proton magnetic resonance spectroscopy protocol was implemented for detection of skeletal muscle acetylcarnitine during the day and after exercise on a clinical 7T scanner in the thigh (vastus lateralis) muscle. Our observation point towards diurnal changes of acetylcarnitine concentration which tended to be higher in the morning than after lunch. Moreover, following 10 minutes of high-intensity exercise the concentration significantly increased and again significantly decreased 15 minutes after cessation of the exercise. Our data emphasize the need for strict standardization,physical activity and dietary conditions for the measurement of the acetylcarnitine/carnitine.

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