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Abstract #4998

Validity of skeletal muscle fiber type distinguished using q-space imaging

Junichi Hata1,2,3, Kanehiro Fujiyoshi2, Osahiko Tsuji2, Yuji Komaki2,3, Keigo Hikishima4, Masaya Nakamura2, and Hideyuki Okano1,2

1RIKEN Brain Science Institute, Saitama, Japan, 2Department of Physiology, Keio University School of Medicine, Tokyo, Japan, 3Central Institute for Experimental Animals, Kanagawa, Japan, 4Okinawa Institute of Science and Technology, Okinawa, Japan

We developed a technology that the muscle composition ratio can be non-invasively visualize at q-space imaging. And, these MR image confirmed validation by comparison to the skeletal muscle histology. We scanned diffusion data using 7T MRI scanner and performed analysis to calculate QSI index. The mice lower leg was stained by several solutions to enable muscle typing. As a result, the cell size by sections showing the correlation between the QSI indices. Moreover, the visualization in a staining compared, it is possible to obtain the same image. We confirmed validation by comparing the stained image to QSI.

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