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Abstract #5007

Magnetic Resonance Methods for Quantitative Evaluation of Intramuscular Adipose Tissue

Alexandra Grimm1,2, Heiko Meyer2, Mathias Nittka2, Esther Raithel2, Oliver Chaudry1, Andreas Friedberger1, Michael Uder3, Wolfgang Kemmler1, Klaus Engelke1, and Harald H. Quick1,4,5

1Institute of Medical Physics, University Erlangen-Nuremberg, Erlangen, Germany, 2Product Definition & Innovation, Siemens Healthcare GmbH, Diagnostic Imaging, Magnetic Resonance, Erlangen, Germany, 3Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 4Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany, 5High Field and Hybrid MR Imaging, University Hospital Essen, Essen, Germany

Intramuscular adipose tissue directly affects physical performance. 56 subjects (80 ± 5 yrs) with sarcopenia and 23 physically well-trained subjects (28 ± 4 yrs), all male, were examined at the thigh on a 3T MR system using quantitative MRI and MRS sequences. The results show that the use of spectroscopy involves challenges with regard to representative assessment of the entire muscle and might overestimate fat in low-fat tissues as muscle tissue. Furthermore, 2pt in comparison to 6pt Dixon sequences should be used with caution for quantitative evaluation, while multi-echo Dixon sequences are capable of quantifying intramuscular adipose tissue.

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