Intramuscular adipose tissue directly affects physical performance. 56 subjects (80 ± 5 yrs) with sarcopenia and 23 physically well-trained subjects (28 ± 4 yrs), all male, were examined at the thigh on a 3T MR system using quantitative MRI and MRS sequences. The results show that the use of spectroscopy involves challenges with regard to representative assessment of the entire muscle and might overestimate fat in low-fat tissues as muscle tissue. Furthermore, 2pt in comparison to 6pt Dixon sequences should be used with caution for quantitative evaluation, while multi-echo Dixon sequences are capable of quantifying intramuscular adipose tissue.
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