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Abstract #5015

Type 2 diabetes alters bone marrow fat content and marrow blood flow as seen by IDEAL-IQ and DCE MRI

Lin Yuan1, Zha Yunfei1, Lin Hui2, and Wu Bing2

1Renmin Hospital of Wuhan University, wuhan, People's Republic of China, 2GE healthcare, wuhan, China

To explore the effect of type 2 diabetes on bone marrow fat contnent(BMF) and marrow blood flow, as well as the association of the bone marrow fat contnent and marrow perfusion in type 2 diabetes mellitus (T2DM) patients. 26 healthy nondiabetic subjects and 24 T2DM patients underwent lumbar IDEAL-IQ and DCE-MRI. The marrow fat content(BMF) and the marrow perfusion parameters (Ktrans, Kep, Ve) of lumbar vertebra all showed significant difference between T2DM patients and the healthy individuals. In addition, transfer constant (Ktrans) was negatively correlated with BMF in T2DM patients.

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