Meeting Banner
Abstract #5039

How to spend your time? Using multi-echo acquisition versus increasing sampling rate in resting-state fMRI

Daniele Mascali1, Keith Jamison2, Emily Kittelson2, Kâmil Uğurbil2, Essa Yacoub2, Shalom Michaeli2, Melissa Terpstra2, Federico Giove1, and Silvia Mangia2

1Museo Storico della Fisica e Centro Studi e Ricerche “Enrico Fermi”, Rome, Italy, 2Center for Magnetic Resonance Research, Dept. of Radiology, University of Minnesota, Minneapolis, MN, United States

High sampling rate is pivotal for differentiating neuronal-related from spurious correlations in resting-state-fMRI (rsfMRI). Acquiring multi-echoes (ME) during an EPI readout increases contrast-to-noise, but it can compromise temporal resolution even when combined with multiband (MB). Therefore, whether MBME-EPI is ultimately beneficial for rsfMRI remains unclear. To address this, we collected data at 3T with 2-mm resolution using MBME-EPI and the human-connectome-project MB-single-echo-EPI. Data were evaluated for spectral amplitude, consistency and specificity. MBME-EPI showed significant gains in all quantities when physiological noise and sampling rate were matched between time-series. However, there was no clear gain when different sampling rates were considered.

This abstract and the presentation materials are available to members only; a login is required.

Join Here