In vivo human brain imaging under highly inhomogeneous B0 field of 250 kHz off-resonance variation over 20 cm is demonstrated. The B0 field inhomogeneity was generated by mounting a head gradient coil at 36 cm off the isocenter of a 90-cm 4T magnet. Brain imaging was performed with 3D missing-pulse steady-state free precession using the inhomogeneous field gradient for spatial (readout) encoding. Frequency-modulated pulses were employed to excite the widely distributed spin frequencies in the inhomogeneous field with easily achievable RF peak power (~1 kW). By providing combined T1, T2, and high diffusion weighting, images with clear delineation of brain anatomy were produced.
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