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Abstract #5052

Magnetic Resonance Imaging under Highly Inhomogeneous B0 Fields using Missing-Pulse Steady-State Free Precession (MP-SSFP)

Naoharu Kobayashi1, Djaudat Idiyatullin1, Gregor Adriany1, and Michael Garwood1

1Center for Magnetic Resonance Research,Department of Radiology, University of Minnesota, Minneapolis, MN, United States

In vivo human brain imaging under highly inhomogeneous B0 field of 250 kHz off-resonance variation over 20 cm is demonstrated. The B0 field inhomogeneity was generated by mounting a head gradient coil at 36 cm off the isocenter of a 90-cm 4T magnet. Brain imaging was performed with 3D missing-pulse steady-state free precession using the inhomogeneous field gradient for spatial (readout) encoding. Frequency-modulated pulses were employed to excite the widely distributed spin frequencies in the inhomogeneous field with easily achievable RF peak power (~1 kW). By providing combined T1, T2, and high diffusion weighting, images with clear delineation of brain anatomy were produced.

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