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Abstract #5069

Muscle Change Associated with Time in Intensive Care Unit (ICU)

Michael Perrins1,2, Lucy V Hiscox1, Calum Gray1, Scott Semple1, Lucy Barclay3, Rachael Kirkbride3, Lisa Salisbury3, Colin Brown4, Timothy Walsh3, Edwin J.R van Beek1, Neil Roberts1, and David Griffith3

1Clinical Research Imaging Centre, The University of Edinburgh, Edinburgh, United Kingdom, 2MRC Centre for Inflammation Research, The University of Edinburgh, Edinburgh, United Kingdom, 3Anaesthesia, Critical Care and Pain Medicine, The University of Edinburgh, Edinburgh, United Kingdom, 4The Mentholatum Company Ltd., East Kilbride, United Kingdom

Muscle wasting is common during critical illness. In this study, thigh muscles of previously mobile patients surviving an episode of severe critical illness were imaged by Magnetic Resonance Imaging (MRI) during convalescence and compared to healthy controls. We present preliminary findings of the first clinical study using Magnetic Resonance Elastography (MRE) to measure muscle stiffness (kPa) and muscle cross-sectional area (mm2) for Intensive Care Unit (ICU) patients. A statistically significant reduction in muscle area and muscle stiffness in patients was found when compared to the healthy control group. There was a significant cross-sectional muscle area increase following ICU patient discharge.

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