Abstract #5069

Muscle Change Associated with Time in Intensive Care Unit (ICU)

Michael Perrins^1,2, Lucy V Hiscox¹, Calum Gray¹, Scott Semple¹, Lucy Barclay³, Rachael Kirkbride³, Lisa Salisbury³, Colin Brown⁴, Timothy Walsh³, Edwin J.R van Beek¹, Neil Roberts¹, and David Griffith³

¹Clinical Research Imaging Centre, The University of Edinburgh, Edinburgh, United Kingdom, ²MRC Centre for Inflammation Research, The University of Edinburgh, Edinburgh, United Kingdom, ³Anaesthesia, Critical Care and Pain Medicine, The University of Edinburgh, Edinburgh, United Kingdom, ⁴The Mentholatum Company Ltd., East Kilbride, United Kingdom

Muscle wasting is common during critical illness. In this study, thigh muscles of previously mobile patients surviving an episode of severe critical illness were imaged by Magnetic Resonance Imaging (MRI) during convalescence and compared to healthy controls. We present preliminary findings of the first clinical study using Magnetic Resonance Elastography (MRE) to measure muscle stiffness (kPa) and muscle cross-sectional area (mm²) for Intensive Care Unit (ICU) patients. A statistically significant reduction in muscle area and muscle stiffness in patients was found when compared to the healthy control group. There was a significant cross-sectional muscle area increase following ICU patient discharge.

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