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Abstract #5083

Personalized map to assess diffuse and focal brain damage

Guillaume Bonnier1, Alexis Roche2,3, Tom Hilbert3,4,5, Gunnar Krueger6, Cristina Granziera1,7, and Tobias Kober4

1MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, 2Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 3Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, 4Siemens Healthcare AG, Advanced Clinical Imaging Technology, Lausanne, Switzerland, 5LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 6Siemens Medical Solutions USA, Inc., Malvern, MA, United States, 7Neuroimmunology Unit, Neurology, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

We propose a new methodology, which is based on the quantification of region-specific brain tissue-properties to provide personalize maps of brain damage in a single patient. To achieve this aim, we used T1, T2, T2* and MTI maps and applied the method to detect brain abnormalities in multiple sclerosis patients.

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