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Abstract #5102

Orientation anisotropy of quantitative MRI relaxation parameters in articular cartilage

Nina Hänninen1, Jari Rautiainen1, Lassi Rieppo2,3, Simo Saarakkala2,3,4, and Mikko Johannes Nissi1,5

1Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, 2Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 3Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland, 4Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland, 5Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland

Classical and several rotating frame quantitative MR relaxation parameters have been used for evaluation of composition and structure of articular cartilage, and demonstrated to have variable sensitivity to orientation of the tissue in magnetic field. The orientation dependence of several relaxation parameters in articular cartilage have been previously investigated and were now further analyzed and compared to polarized light microscopy results. T1, adiabatic T with HS1 pulse and CW-T at 2 kHz spin-lock demonstrated the least orientation dependence. Usefulness of the parameters for osteoarthritis diagnostics, as reported in the literature, was evaluated together with the orientation sensitivity.

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