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Abstract #5115

Measuring fat unsaturation and polyunsaturation in vertebral bone marrow using dynamic inversion-recovery single-voxel spectroscopy

Stefan Ruschke1, Andreas Hock2, Dominik Weidlich1, Ernst J. Rummeny1, Jan S. Kirschke3, Thomas Baum1, Roland Krug4, and Dimitrios C. Karampinos1

1Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, 2Philips Healthcare, Hamburg, Germany, 3Department of Neuroradiology, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany, 4Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

The assessment of vertebral bone marrow fat unsaturation is attracting growing interest for applications in bone metabolism and osteoporosis. Especially in younger subjects, the presence of a strong and broad water peak confounds the extraction of surrounding peaks (olefinic and glycerol peaks), which are used for the determination of fat unsaturation. Inversion-recovery spectroscopy allows the extraction of these peaks by differentiating the signals based on different T1 relaxation times between water and fat. The feasibility of using inversion-recovery spectroscopy was evaluated in a phantom experiment in comparison with gas chromatography and in vivo in four young and healthy volunteers.

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