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Abstract #5121

MRE derived stiffness of the gluteus maximus muscle: reproducibility and correlation to T2 and fat-fraction

Jules L. Nelissen1,2, Dorien Verschuren1, Larry de Graaf1, Cees W. J. Oomens3, Klaas Nicolay1, Ralph Sinkus4, Jurgen H. Runge4,5, Aart J. Nederveen5, and Gustav J. Strijkers2

1Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands, 2Preclinical and Translational MRI, Academic Medical Center, Amsterdam, Netherlands, 3Biomechanics of Soft Tissues, Eindhoven University of Technology, Eindhoven, Netherlands, 4Division of Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom, 5Radiology, Academic Medical Center, Amsterdam, Netherlands

Skeletal muscle pathology is often accompanied by abnormal fat deposition, fibrosis, and edema. Altered muscle biomechanical properties associated with these compositional changes can be quantitatively assessed with MRE. We present MRE measurements of the gluteus maximus muscle. In healthy volunteers, we have tested reproducibility and correlated the shear modulus Gd to T2 and fat-fraction FFdix measured using Dixon. Acceptable intra and inter reproducibility was found. Expected difference in Gd between gluteus maximus and subcutaneous fat was confirmed. Correlation plots of T2 and FFdix with Gd showed that MRE can derive biomechanical properties that potentially can provide additional information to characterize skeletal muscle pathology.

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